It is a drug that is classified as a reversible, potent and selective inhibitor of phosphodiesterase 5 (PDE5). Given its characteristics, this medicine should only be used under medical prescription.

In which situations should this drug be used?

시알리스 구매 drug has been used for almost 20 years and its effects are well known. However, it is important that you make the rational use of this medicine, that is, use it properly, in the right dose and for the time stipulated by your doctor.

Medication may be indicated in the following situations:

Difficulty obtaining and/or maintaining a penile erection ( erectile dysfunction )

Enlarged prostate that is characterized by increased urinary frequency, intermittent urination, and straining to urinate (benign prostatic hyperplasia)

Understand how it works

When administered orally, the drug is absorbed and metabolized by the liver, then excreted via the faecal and urinary route.

To understand how it works in your body, it is first necessary to know how penile erection occurs: it results from a neurovascular process that begins through sexual stimulation and promotes the release of nitric oxide (NO) in the arteries existing in the corpora cavernosa. of the penis.

This raises intracellular levels of cyclic guanosine monophosphate (cGMP), which causes muscular and vascular relaxation of the corpora cavernosa, favoring blood flow and penis stiffening.

So that cGMP levels do not remain indefinitely high and erection does not last too long, cGMP is naturally degraded by the phosphodiesterase type 5 enzyme. The explanations are given by pharmacist Leonardo Coutinho Ribeiro.

시알리스 구입 “Tadalafil, as an inhibitor of the enzyme phosphodiesterase type 5, promotes relaxation of the local muscles and restores the erection mechanism in men with erectile dysfunction by increasing the levels of cGMP”, adds the specialist.

When erectile dysfunction and benign enlargement of the prostate are added, the drug also promotes relaxation of the muscles of the gland, bladder and blood vessels, reducing the narrowing of the urethra, and decreasing the symptoms of organ enlargement.

How long does the effect last?

The desired effects are expected to occur within 30 minutes of 시알리스 drug administration, which can last up to 36 hours.

However, the manufacturer warns that tadalafil only promotes erection when there is sexual stimulation. Without it, the drug alone does not lead to an erection.